Monthly Archives: November 2012

We screened for autophagy modulators with 253 FDA approved

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Hermes Replica However Hermes Replica Handbags, demonstration of this combination treatment strategy in mouse models of neurodegenerative disorders is challenging and remains to be investigated.Top of pageAn mTOR Independent Cyclical Autophagy Pathway with Multiple Drug TargetsApart from the classical mTOR pathway regulating mammalian autophagy, we have recently described many of the players in an mTOR independent pathway32 (Figure 3). We screened for autophagy modulators with 253 FDA approved drugs and pharmacological probes by assessing the clearance of autophagy substrates, such as the A30P and A53T mutants of and mutant huntingtin. This screen yielded various autophagy enhancers, such as L type Ca2 channel antagonists, a K channel opener and a Gi signalling activator, whose mechanisms of action were found to be linked in a cyclical fashion. Hermes Replica

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